ATL3 蛋白, Human (His)

ATL3 protein is a GTPase that mediates homotypic fusion of endoplasmic reticulum (ER) membranes by promoting membrane tethering through the formation of trans homomers.ATL3 is critical for ER tubular network biogenesis, contributing to the organization and dynamics of this important cellular structure.ATL3 Protein, Human (His) is the recombinant human-derived ATL3 protein, expressed by E.coli , with N-His labeled tag.

ATL3 蛋白作为 GTP 酶，通过形成反式同聚体促进膜束缚，从而介导内质网 (ER) 膜的同型融合。这种关键蛋白在内质网内管状网络的生物发生中发挥着至关重要的作用，有助于这种重要细胞结构的组织和动力学。此外，ATL3 与特定蛋白质（例如 ZFYVE27 和 REEP5）相互作用，表明分子关联网络进一步调节其在膜动力学和 ER 结构中的功能作用。

Measured by its ability to catalyze the substrate GTP. The specific activity is 613.47 μM/min/μg, as measured under the described conditions.

Human

E. coli

N-10*His

Q6DD88 (M1-A445)

25923  [NCBI]

MLSPQRVAAAASRGADDAMESSKPGPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVAVVLMDTQGAFDSQSTVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLVRDWSFPYEYSYGLQGGMAFLDKRLQVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKLKDIAGEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAEANNLAAAASAKDIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKKMGGKDFSFRYQQELEEEIKELYENFCKHNGSKNVFSTFRTPA

Approximately 52.6 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.