CABP5 蛋白, Human (His)

The CABP5 protein acts as an inhibitor to regulate calcium-dependent inactivation of L-type calcium channels, converting the voltage dependence of activation to a more depolarizing membrane potential. It is involved in the transmission of light signals and may positively regulate endocytosis and exocytosis of neurotransmitter vesicles in a salt-dependent manner. CABP5 Protein, Human (His) is the recombinant human-derived CABP5 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CABP5 Protein, Human (His) is 173 a.a., with molecular weight of ~19 kDa.

CABP5 蛋白起到抑制剂的作用，调节 L 型钙通道的钙依赖性失活，并将激活的电压依赖性转变为更去极化的膜电位。它参与光信号的传递，并可能以盐依赖性方式正向调节神经递质囊泡的内吞作用和胞吐作用。此外，CABP5 可能有助于神经突的延伸和网络组织。该蛋白以钙依赖性方式与 CACNA1C 相互作用，并与 STXBP1 和 MYO6 形成关联。

Human

E. coli

N-6*His

Q9NP86 (M1-R173)

56344  [NCBI]

MQFPMGPACIFLRKGIAEKQRERPLGQDEIEELREAFLEFDKDRDGFISCKDLGNLMRTMGYMPTEMELIELGQQIRMNLGGRVDFDDFVELMTPKLLAETAGMIGVQEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVNGDGTVDFEEFVKMMSR

Approximately 19 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of sterile 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.