CNPY4/PRAT4B 蛋白, Human (HEK293, His)

CNPY4/PRAT4B Protein crucially modulates TLR4 cell surface expression, impacting innate immune system regulation. Its direct interaction with TLR4 shapes Toll-like receptor signaling dynamics, essential for pathogen-associated molecular pattern recognition. By regulating TLR4 expression, CNPY4/PRAT4B fine-tunes immune cell responsiveness, contributing to the delicate balance between activation and regulation in host defense and inflammation. CNPY4/PRAT4B Protein, Human (HEK293, His) is the recombinant human-derived CNPY4/PRAT4B protein, expressed by HEK293 , with C-His labeled tag. The total length of CNPY4/PRAT4B Protein, Human (HEK293, His) is 248 a.a., with molecular weight of ~30 kDa.

CNPY4/PRAT4B 蛋白在调节 TLR4 的细胞表面表达中发挥着至关重要的作用，暗示其在先天免疫系统复杂的调节机制中的重要性。它与 TLR4 的直接相互作用强调了它在塑造 Toll 样受体信号传导动力学方面的功能参与，这是识别病原体相关分子模式的关键途径。通过参与 TLR4 细胞表面表达的调节，CNPY4/PRAT4B 成为微调免疫细胞对细胞外刺激的反应性的关键分子参与者，最终有助于宿主防御中免疫激活和调节之间的微妙平衡和炎症。

Human

HEK293

C-6*His

Q8N129 (G22-L248)

245812  [NCBI]

GMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEEEGGDKMTKTGSHPKLDREDL

Approximately 30 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.