1. 重组蛋白
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. Ephrin/Eph Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. Eph Receptors
  5. EphB2
  6. EphB2 蛋白, Human (sf9, GST)

EphB2 蛋白, Human (sf9, GST)

目录号: HY-P702710
产品使用指南

EphB2 蛋白是一种受体酪氨酸激酶,参与跨膜肝配蛋白 B 配体的双向信号传导。它引导发育中的大脑皮层的连合轴突、内耳的传出生长锥和视网膜神经节细胞轴突。EphB2 蛋白, Human (sf9, GST) 是重组的 EphB2 蛋白,由 Sf9 insect cells 表达,带有 GST 标签。EphB2 蛋白, Human (sf9, GST) 全长 475 个氨基酸

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描述

EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (sf9, GST) is the recombinant human-derived EphB2, expressed by Sf9 insect cells , with GST labeled tag. The total length of EphB2 Protein, Human (sf9, GST) is 475 a.a.,

研究背景

EphB2 蛋白是一种受体酪氨酸激酶,与邻近细胞上的跨膜肝配蛋白-B 配体相互作用,产生双向信号传导。EphB2 下游的通路称为正向信号传导,而肝配蛋白配体下游的通路称为反向信号传导。EphB2在发育过程中的轴突引导中发挥着至关重要的作用,特别是在连接大脑皮层颞叶的连合轴突的引导,以及内耳传出生长锥和视网膜神经节细胞轴突的引导中。它还调节树突棘的发育和成熟,促进兴奋性突触的形成,抵消 EFNB1 激活后 ARHGEF15 介导的负调节。此外,EphB2 参与各种发育过程,包括血管生成、上颚发育和内耳内淋巴生成。它与 EFNB2 的复合物控制尿道管状化和泄殖腔分隔过程中的细胞运动和粘附。此外,EphB2 可能具有肿瘤抑制活性,并可能影响血小板活化和凝血。

种属

Human

表达系统

Sf9 insect cells

标签

GST

蛋白编号

P29323-1 (L581-G1055)

基因 ID

2048

同用名
EPHB2; EPH receptor B2; DRT, EphB2 , EPHT3, ERK; ephrin type-B receptor 2; Hek5; Tyro5; EPH-like kinase 5; eph tyrosine kinase 3; elk-related tyrosine kinase; protein-tyrosine kinase HEK5; tyrosine-protein kinase TYRO5; renal carcinoma antigen NY-REN-47; tyrosine-protein kinase receptor EPH-3; developmentally-regulated Eph-related tyrosine kinase; DRT; EK5; ERK; CAPB; PCBC; EPHT3; MGC87492
纯度

Greater than 80 % as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
EphB2 Protein, Human (sf9, GST)
目录号:
HY-P702710
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