FGF-21 蛋白, Human

FGF-21 Protein, Human is an atypical member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.

人成纤维细胞生长因子 21 (FGF21) 以内分泌方式发挥作用，是一种具有多效性的代谢调节剂。FGF21 对心血管系统具有保护作用，主要是由于代谢作用而不是维持能量稳态。FGF21 还参与多个过程，包括减少主要血管中动脉硬化斑块的形成，并保护心肌免受梗塞、缺血再灌注、异丙肾上腺素诱导的肥大和糖尿病脂毒性引起的损伤。此外，FG2F1 通过减轻重塑相关的炎症和氧化应激、促进心肌能量代谢以及防止脂质或糖尿病诱导的心肌细胞凋亡来诱导这些作用。FGF21 在共受体 β-Klotho 的帮助下通过与 FGF 受体 (FGFR) 的相互作用发挥作用。从结构上看，FGFR 分为四种亚型：FGFR1-FGFR4^[1]。

The ED₅₀ is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of > 2.0 × 10³ units/mg.

Human

E. coli

Tag Free

Q9NSA1 (H29-S209,with an N-terminal Gly)

26291  [NCBI]

GHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS

Approximately 19.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<1.0 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Cao F, et al. Fibroblast growth factor 21 attenuates calcification of vascular smooth muscle cells in vitro. J Pharm Pharmacol. 2017 Dec;69(12):1802-1816.  [Content Brief]