FGFR-1 alpha (IIIb) 蛋白, Human (HEK293, His)

FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-His, C-10*His labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His), has molecular weight of 60-90 kDa.

成纤维细胞生长因子受体 1 α (FGFR1) 是 FGFR 家族的成员，与其他家族成员共享高度保守的氨基酸序列，并表现出不同的配体亲和力和组织分布。FGFR1 在其胞外区域包含三个免疫球蛋白样结构域、一个跨膜片段和一个细胞质酪氨酸激酶结构域，在转导成纤维细胞生长因子引发的信号中发挥着关键作用。它结合酸性和碱性成纤维细胞生长因子，影响有丝分裂和分化，特别是在肢体诱导中。FGFR1 突变与多种综合征相关，包括 Pfeiffer 综合征、Jackson-Weiss 综合征和 Kallmann 综合征 2，以及骨发育不良等疾病。涉及该基因的染色体畸变与干细胞骨髓增殖性疾病和干细胞白血病淋巴瘤综合征有关。已鉴定出编码不同蛋白质亚型的各种选择性剪接变体，这些变体有助于 FGFR1 的功能多样性。该基因在组织中普遍表达，在卵巢 (RPKM 21.8)、脂肪 (RPKM 21.4) 和 25 个其他组织中表达水平显着。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-His

NP_056934 (R22-K310&A359-E374)&AAB19502 (H1-P47)

2260  [NCBI]

A1:
RPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
A2:
ALEERPAVMTSPLYLE
A3:
HSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRP

60-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.