GBP2 蛋白, Human (HEK293, His)

CBP2 is an interferon-induced guanylate-binding protein. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 can up-regulate GBP2 and play an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins. GBP2 Protein, Human (HEK293, His) is the recombinant human-derived GBP2 protein, expressed by HEK293 , with C-His labeled tag.

干扰素是具有抗病毒作用和抑制肿瘤细胞增殖的细胞因子。它们在靶细胞中诱导大量基因，包括编码鸟苷酸结合蛋白 (GBPs) 的基因。小鼠 GBP2 基因不仅在巨噬细胞激活过程中被干扰素-γ 高度激活，而且还受到 toll 样受体、肿瘤坏死因子 (TNF) 和白细胞介素 1 β 的刺激。GBP2 在调节细胞增殖和抵抗病原体感染方面具有重要作用。p53 可上调 GBP2，并通过抑制金属蛋白酶 MM9、 NF-Kappa B 和 Rac 蛋白在肿瘤发生发展中发挥重要作用。

Human

HEK293

C-10*His

AAH73163.1 (M1-C588)

2634  [NCBI]

MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCRENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPIC

Approximately 60-75 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.