HIST3H2A 蛋白, Human

The HIST3H2A protein is a core component of nucleosomes that compact DNA into chromatin. HIST3H2A Protein, Human is the recombinant human-derived HIST3H2A protein, expressed by E. coli , with tag free. The total length of HIST3H2A Protein, Human is 129 a.a., with molecular weight of 15-20 KDa.

HIST3H2A 作为核小体的核心成分，参与将 DNA 包裹和压缩到染色质中的基本过程，从而限制 DNA 进入依赖 DNA 作为模板的细胞机器。这种组蛋白与其他蛋白一样，在转录调节、DNA 修复、DNA 复制和维持染色体稳定性等关键细胞功能中发挥着关键作用。DNA 可及性的复杂控制涉及复杂的翻译后修饰系统（称为组蛋白密码）以及动态核小体重塑。核小体本身是一种组蛋白八聚体，包含 H2A、H2B、H3 和 H4 各两个分子，组装成一个 H3-H4 异四聚体和两个 H2A-H2B 异二聚体。这种八聚体有效地包裹了大约 147 个碱基对的 DNA，强调了它在组织染色质结构和促进基本基因组过程中的关键作用。

Human

E. coli

Tag Free

Q7L7L0 (S2-K130)

92815  [NCBI]

SGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

15-20 kDa.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.