TMEM219/IGFBP-3R 蛋白, Mouse (HEK293, Fc)

The IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and becomes a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This receptor actively interacts with IGFBP3, forming a key molecular connection that may initiate the apoptotic signaling cascade. TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag.

IGFBP-3R 是一种对胰岛素样生长因子结合蛋白 3 (IGFBP3) 具有特异性的细胞死亡受体，参与配体结合后介导 caspase-8 依赖性细胞凋亡。该受体直接与 IGFBP3 相互作用，表明在转导与细胞生存和死亡途径相关的信号中发挥着关键作用。IGFBP3 与 IGFBP-3R 的结合可能引发细胞凋亡级联，可能涉及 caspase-8。IGFBP-3R 和 caspase-8 之间的相互作用强调了该受体在调节细胞凋亡过程中的潜在参与。

Mouse

HEK293

C-hFc

Q9D123-1 (G39-R204)

68742  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.