IGFBP-5 蛋白, Mouse (HEK293, His)

IGFBP-5 protein is a member of the IGFBP family that significantly prolongs the half-life of IGF and modulates its growth-promoting effects in cell culture. The multifunctional IGFBP-5 can inhibit or stimulate cellular responses to IGF by altering the kinetics of interaction with IGF receptors. IGFBP-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGFBP-5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-5 Protein, Mouse (HEK293, His) is 252 a.a., with molecular weight of ~38.0 kDa.

IGFBP-5 蛋白是胰岛素样生长因子结合蛋白 (IGFBP) 的成员，在延长胰岛素样生长因子 (IGF) 的半衰期和调节其对细胞培养的生长促进作用方面发挥着至关重要的作用。IGFBP-5 具有多功能性，已被证明可以抑制或刺激 IGF 引发的细胞反应。IGFBP-5 通过改变 IGF 与其相应细胞表面受体之间的相互作用动力学来实现这种调节功能。通过控制这些分子相互作用，IGFBP-5 有助于 IGF 信号通路的复杂调节，影响与生长和发育相关的细胞反应。IGFBP-5 的多种作用强调了它在控制 IGF 与其受体之间相互作用的调控框架中的重要性。

Mouse

HEK293

C-6*His

Q07079 (L20-E271)

16011  [NCBI]

LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE

Approximately 38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.