IL-12 beta 蛋白, Cynomolgus (HEK293, His)

IL-12 beta Protein, partnering with IL23A, produces the cytokine IL-23 vital in innate and adaptive immunity. Alongside IL-17, IL-23 orchestrates an immediate infection response in peripheral tissues. Binding to IL12RB1 and IL23R, IL-23 activates Jak-Stat signaling, preferentially stimulating memory T-cells, and induces pro-inflammatory cytokine production. Implicated in autoimmune inflammation and tumorigenesis, IL-23 serves as a growth factor for activated T and NK cells, enhances NK cell lytic activity, and triggers IFN-gamma production by resting PBMC. IL-12 beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-12 beta protein, expressed by HEK293, with C-His labeled tag. The total length of IL-12 beta Protein, Cynomolgus (HEK293, His) is 306 a.a., with molecular weight of 40-50 kDa.

IL-12 β 蛋白与 IL23A 结合，形成 IL-23 白细胞介素，这是一种异二聚体细胞因子，在先天免疫和适应性免疫中具有重要功能。IL-23 与 IL-17 结合，可以协调外周组织对感染的立即反应。通过与包含 IL12RB1 和 IL23R 的异二聚体受体复合物结合，IL-23 启动 Jak-Stat 信号级联，优先刺激记忆 T 细胞而不是幼稚 T 细胞，并促进促炎细胞因子的产生。IL-23 参与自身免疫性炎症的诱导，可能在自身免疫性炎症疾病和肿瘤发生中发挥至关重要的作用。此外，该细胞因子充当激活的 T 和 NK 细胞的生长因子，放大 NK/淋巴因子激活的杀伤细胞的裂解活性，并通过静息 PBMC 触发 IFN-γ 的产生。

Cynomolgus

HEK293

C-His

A0A2K5TM36 (I23-S328)

102124858

40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.