IL-21 蛋白, Rat

IL-21 Protein, crucial in immune responses and lymphocyte activation, exhibits biased expression in tissues like the thymus and spleen. Predicted to be active in the extracellular space, it serves as a biomarker for periodontal disease and is implicated in conditions like asthma, hepatocellular carcinoma, and systemic lupus erythematosus. IL-21 Protein, Rat is the recombinant rat-derived IL-21 protein, expressed by E. coli , with tag free.

IL-21 蛋白预计具有白细胞介素 2 受体结合活性，并预计参与多种过程，包括免疫反应中的淋巴细胞激活、免疫效应过程的正向调节以及 STAT 蛋白的酪氨酸磷酸化。此外，预计 IL-21 在细胞因子产生的正向调节、淋巴细胞活化的正向调节以及 STAT 蛋白的酪氨酸磷酸化的正向调节等过程的上游或内部发挥作用。该蛋白质预计位于细胞外空间。IL-21 作为牙周病的生物标志物，与多种人类疾病有关，包括哮喘、常见变异型免疫缺陷病、肝细胞癌和系统性红斑狼疮。值得注意的是，IL-21 在胸腺和脾脏等组织中表现出偏向表达，表明其在这些器官内的免疫调节中具有潜在作用。

Measured by its binding ability in a functional ELISA. Immobilized Rat IL-21 at 5 μg/mL (100 μL/well) can bind Biotinylated Rat IL-21R Protein. The ED₅₀ for this effect is 12.16 ng/mL.

Rat

E. coli

Tag Free

A3QPB9/NP_001102413.1 (P25-S146)

365769  [NCBI]

PDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS

Approximately 16 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.