KIF11 蛋白, Human

KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free. The total length of KIF11 Protein, Human is 368 a.a., .

KIF11 蛋白在细胞过程中发挥着关键作用，作为有丝分裂期间双极纺锤体形成的关键运动蛋白。它的重要性超出了有丝分裂活动，因为 KIF11 在非有丝分裂细胞中至关重要，可促进分泌蛋白从高尔基复合体运输到细胞表面。值得注意的是，KIF11 参与复杂的相互作用，包括在甲状腺激素存在的情况下与甲状腺激素受体的结合。此外，KIF11 与 MYSM1、PCAF 和 RBM10 一样，是重要染色质重塑复合物的关键组成部分，突出了它在染色质动力学中的参与。该蛋白在间期和有丝分裂期间进一步与激酶 NEK6 相互作用，特别是通过其 C 末端，展示了其多功能作用。此外，KIF11 表现出与 RARRES1 和 AGBL2 的相互作用，强调其在各种细胞途径中的多样化参与。

Human

E. coli

Tag Free

P52732 (M1-K368)

3832

MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK

Approximately 41 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 5% glycerol, 1 mM DTT, 2 mM MgCl₂, pH 7.0.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.