MYOZ2 蛋白, Human (His)

MYOZ2 is a member of the Myozenin family that binds to Z-line proteins, including α-actin and γ-filamin, and contributes to the localization of calcineurin signals within the sarcomere. It plays a key role in regulating calcineurin signaling and has been shown to be involved in muscle regulatory mechanisms and myofibril formation. MYOZ2 Protein, Human (His) is the recombinant human-derived MYOZ2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of MYOZ2 Protein, Human (His) is 264 a.a., with molecular weight of ~38.0 kDa.

MYOZ2 是 Myozenin 家族的成员，作为细胞内结合蛋白发挥作用，促进 Z 线蛋白（例如 α-肌动蛋白、γ-丝蛋白、TCAP/telethonin 和 LDB3/ZASP）的连接，从而有助于钙调神经磷酸酶的定位肌节内的信号传导。这种蛋白质在调节钙调神经磷酸酶信号传导中至关重要，表明它参与了肌肉功能的复杂调节机制。此外，MYOZ2 可能在肌原纤维形成中发挥至关重要的作用。MYOZ2 通过其 C 末端与 ACTN2 的血影蛋白重复序列 3 和 4 相互作用，并与其他蛋白质（包括 ACTN1、LDB3、MYOT 和 PPP3CA）相互作用。这些相互作用凸显了 MYOZ2 在介导对肌节结构和信号完整性至关重要的分子连接方面的重要性。

Human

E. coli

C-6*His

Q9NPC6 (M1-L264)

51778  [NCBI]

MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL

Approximately 38.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.