Neuroligin-3/NLGN3 蛋白, Human (HEK293, His)

Neuroligin-3 (NLGN3) Protein, a cell surface protein, engages in cell-cell interactions by interacting with neurexin family members. It influences synapse function and signal transmission, potentially by clustering synaptic proteins. NLGN3 may facilitate initial synapse formation but is not indispensable for it. Additionally, it may participate in glia-glia or glia-neuron interactions during peripheral nervous system development. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins and DLG4/PSD-95. Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is the recombinant human-derived Neuroligin-3/NLGN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is 652 a.a., with molecular weight of 100-110 KDa.

Neuroligin-3 (NLGN3) 是一种细胞表面蛋白，通过与神经毒素家族成员的相互作用，在细胞间相互作用中发挥着至关重要的作用。它可能通过聚集其他突触蛋白来参与突触功能和突触信号传递。虽然 NLGN3 可能促进突触的初始形成，但它对于这个过程并不是必需的。此外，它可能参与发育中的周围神经系统中的神经胶质-神经胶质或神经胶质-神经元相互作用。 NLGN3 与 NLGN1 和 NLGN2 形成同二聚体和异二聚体，并与神经毒素 NRXN1、NRXN2 和 NRXN3 相互作用，这种相互作用是由神经毒素上的硫酸乙酰肝素聚糖修饰介导的。此外，NLGN3 通过其 C 末端与 DLG4/PSD-95 相互作用，特别是与 DLG4/PSD-95 的 PDZ 结构域 3 相互作用。

Human

HEK293

C-His

Q9NZ94-2 (Q38-S689)

54413  [NCBI]

MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELS

100-110 kDa.

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.