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  4. PCDH7 蛋白, Human (sf9, His)

PCDH7 蛋白, Human (sf9, His)

目录号: HY-P75956
产品使用指南

PCDH7 蛋白是一种整合膜蛋白，属于 PCDHδ1 亚家族，在大脑和心脏中高表达。PCDH7 是一种突触定位的 GluN1 相互作用蛋白，可调节突触形态和功能。PCDH7 是第一个抑制 hoCIC 形成以促进肿瘤生长的跨膜蛋白PCDH7 蛋白, Human (sf9, His) 是重组的 PCDH7 蛋白，由 Sf9 insect cells 表达，带有 N-His 标签。

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100 μg   询价  

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描述

PCDH7 Protein, an integral membrane protein, belongs to the PCDHδ1 subfamily and it is highly expressed in brain and heart. PCDH7 is a synaptically localized, GluN1-interacting protein that regulates synapse morphology and function. PCDH7 is the first trans-membrane protein that inhibits homotypic cell-in-cell (hoCIC) formation to promote tumor growth[1][2]. PCDH7 Protein, Human (sf9, His) is the recombinant human-derived PCDH7 protein, expressed by Sf9 insect cells , with N-His labeled tag.
研究背景

PCDH7作为第一个跨膜蛋白，抑制 hoCIC 形成以促进肿瘤生长。PCDH7 过度表达会降低突触 NMDA 受体电流。PCDH7可以调节树突棘形态和突触功能。PCDH7 在大脑中高表达，与中枢神经系统疾病(包括癫痫)有关。PCDH7 增加 pMLC2 的水平，导致细胞间区域的肌动球蛋白增强并损害 hoCIC 的形成[2]。
种属

Human
表达系统

Sf9 insect cells
标签

N-His
蛋白编号

O60245-1/NP_002580.2 (A29-S879)
基因 ID
蛋白结构
N-term
His
PCDH7 (A29-S879)
Accession # O60245-1/NP_002580.2
C-term
同用名
Protocadherin-7; Brain-heart protocadherin; BH-Pcdh; PCDH7; BHPCDH
分子量

Approximately 94 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PCDH7 Protein, Human (sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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