RBP4 蛋白, Human (HEK293, hFc)

RBP4 protein acts as a retinol-binding protein, essential for transporting retinol in blood plasma. It facilitates the delivery of retinol from the liver to peripheral tissues and likely transfers bound all-trans retinol to STRA6 for cell membrane transport. Interactions with TTR prevent kidney glomeruli filtration loss. Direct interaction with STRA6 underscores RBP4's role in intricate retinol transport and distribution processes in the body. RBP4 Protein, Human (HEK293, hFc) is the recombinant human-derived RBP4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of RBP4 Protein, Human (HEK293, hFc) is 183 a.a., with molecular weight of ~50 kDa.

RBP4蛋白作为视黄醇结合蛋白，在介导视黄醇在血浆中的转运中发挥着至关重要的作用。它涉及将视黄醇从肝脏储存输送到外周组织，并且它可能将结合的全反式视黄醇转移到 STRA6，促进视黄醇跨细胞膜的转运。RBP4 与 TTR 相互作用，这种关系有助于防止其通过肾小球过滤而损失。此外，该蛋白质直接与 STRA6 相互作用，加强其在体内视黄醇运输和分布的复杂过程中的参与。

Measured by its binding ability in a functional ELISA. Immobilized RBP4 at 5 μg/mL can bind TTR , the EC₅₀ is 800-2912 ng/mL.

Human

HEK293

C-hFc

P02753 (E19-L201)

5950  [NCBI]

ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

Approximately 53 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.