SCN3B 蛋白, Human (HEK293, His)

The SCN3B protein critically affects sodium channel dynamics, inducing unique sustained currents and slower inactivation rates compared to beta-1. Its interaction with NFASC is shown to guide sodium channels to the nodes of Ranvier during axonal development and retain them in mature myelinated axons. SCN3B Protein, Human (HEK293, His) is the recombinant human-derived SCN3B protein, expressed by HEK293 , with C-His labeled tag. The total length of SCN3B Protein, Human (HEK293, His) is 137 a.a., with molecular weight of 23-34 kDa, respectively.

SCN3B 蛋白在调节通道门控动力学方面发挥着至关重要的作用，从而产生独特的持续钠电流。与 beta-1 亚基相比，SCN3B 诱导钠通道失活速度较慢，从而影响其开放动态。SCN3B 与 NFASC 的相互作用表明，它可能参与轴突发育过程中将钠通道引导至 Ranvier 节点并将其保留在成熟有髓轴突的这些节点处。电压敏感钠通道包含离子传导的成孔α亚基，受到β-1、β-2、β-3和/或β-4亚基的复杂调节。值得注意的是，β-1和β-3与α非共价结合，而β-2和β-4通过二硫键形成共价键，从而导致钠通道复合物的功能复杂性。

Human

HEK293

C-6*His

Q9NY72 (F23-E159)

55800  [NCBI]

FPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSE

Approximately 23-34 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.