TCblR/CD320 蛋白, Human (HEK293, His)

TCblR/CD320 is the receptor for cobalamin (TCbl) and is critical for cellular cobalamin homeostasis and B cell responses. It is expressed on follicular dendritic cells, interacts with germinal center B cells, and coordinates immune responses. TCblR/CD320 Protein, Human (HEK293, His) is the recombinant human-derived TCblR/CD320 protein, expressed by HEK293 , with C-6*His labeled tag.

TCblR/CD320 是钴胺素饱和转钴胺素 (TCbl) 的受体，是钴胺素摄取的关键参与者，强调其在细胞钴胺素稳态中的重要性。这种质膜蛋白在滤泡树突细胞 (FDC) 上显着表达，促进与生发中心 B 细胞的相互作用，有助于协调免疫反应。除了在钴胺素转运中发挥作用外，TCblR/CD320 还充当共刺激剂，促进 B 细胞对抗原刺激的反应。这种参与包括 B 细胞分化和增殖的增强，特别是在生发中心 B 细胞内。TCblR/CD320 与生发中心 B 细胞、T 细胞和滤泡树突细胞的复杂相互作用对于记忆 B 细胞和浆细胞的分化至关重要，强调了其在免疫调节中的多方面作用。此外，TCblR/CD320 与 TCN2 的相互作用进一步阐明了它参与钴胺素相关过程，有助于我们了解其不同的细胞功能。

Human

HEK293

C-6*His

Q9NPF0-1 (S36-V231)

51293  [NCBI]

SPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGV

37-53 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-Citrate,150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.