2. 重组蛋白
  3. Receptor Proteins
  4. TIM-1/KIM-1/HAVCR 蛋白, Cynomolgus (HEK293, His)

TIM-1/KIM-1/HAVCR 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P701042
产品使用指南

HAVCR1 是一种表达于免疫细胞表面的共刺激分子，促进免疫细胞的活化和增殖，促进细胞因子的分泌，调节免疫应答。HAVCR1 通过抑制 MEK/ERK 通路并影响肿瘤进展和患者预后。TIM-1/KIM-1/HAVCR 蛋白, Cynomolgus (HEK293, His) 是重组的 TIM-1/KIM-1/HAVCR 蛋白，由 HEK293 表达，带有 C-His 标签。TIM-1/KIM-1/HAVCR 蛋白, Cynomolgus (HEK293, His) 全长 320 个氨基酸，分子量为 100-150 kDa。

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100 μg   询价  

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描述

HAVCR1 is a co-stimulatory molecule expressed on the surface of immune cells, which promotes the activation and proliferation of immune cells, promotes the secretion of cytokines, and regulates immune response. HAVCR1 affects tumor progression and patient prognosis by inhibiting the MEK/ERK pathway. TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is 320 a.a., with molecular weight of 100-150 kDa.
研究背景

甲型肝炎病毒细胞受体 (HAVCR1)，也被称为 T 细胞免疫球蛋白粘蛋白受体 1 (TIM-1) 和肾损伤分子 1 (KIM-1)。HAVCR1 是一种表达于免疫细胞表面的共刺激分子，促进免疫细胞的活化和增殖，促进细胞因子的分泌，调节免疫应答。HAVCR1 通过抑制 MEK/ERK 通路并影响肿瘤进展和患者预后。
种属

Cynomolgus
表达系统

HEK293
标签

C-His
蛋白编号

A0A2K5WXJ6 (V23-G342)
基因 ID

/
蛋白结构
N-term
TIM-1 (V23-G342)
Accession # A0A2K5WXJ6
His
C-term
同用名
HAVcr-1; KIM-1; KIM1; TIMD-1; TIMD1; TIM; TIM-1; TIM1; CD365; HAVCR1; HAVCR; HAVCR-1
分子量

100-150 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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