2. 重组蛋白
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. Trk Receptors TrkC
  6. TrkC 蛋白, Human (HEK293, His-Fc)

TrkC 蛋白, Human (HEK293, His-Fc)

目录号: HY-P73464
COA 产品使用指南

TrkC 蛋白是一种受体酪氨酸激酶，对神经系统和潜在的心脏发育至关重要。NTF3/neurotropin-3 结合后，TrkC 发生自磷酸化，激活磷脂酰肌醇 3-激酶/AKT 和 MAPK 等途径。这些途径调节细胞存活和分化，强调 TrkC 在发育过程中重要细胞过程中的关键作用。TrkC 蛋白, Human (HEK293, His-Fc) 是重组的 TrkC 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。

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100 μg ￥3850 询问价格 & 货期

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描述

TrkC Protein, a receptor tyrosine kinase, crucially contributes to nervous system and potential heart development. Upon NTF3/neurotrophin-3 binding, TrkC undergoes autophosphorylation, activating pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways regulate cell survival and differentiation, emphasizing TrkC's pivotal role in essential cellular processes during development. TrkC Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkC protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
研究背景

TrkC 蛋白是一种受体酪氨酸激酶，在神经系统和潜在心脏发育中发挥着至关重要的作用。与其配体 NTF3/neurotropin-3 结合后，TrkC 发生自磷酸化，启动各种信号传导途径，例如磷脂酰肌醇 3-激酶/AKT 和 MAPK 途径。这些途径有助于调节细胞存活和分化，凸显了 TrkC 在协调发育过程中重要细胞过程中的关键作用。
种属

Human
表达系统

HEK293
标签

C-hFc;C-His
蛋白编号

Q16288-2/NP_001007157.1 (C32-D428)
基因 ID
蛋白结构
N-term
TrkC (C32-D428)
Accession # Q16288-2/NP_001007157.1
hFc-His
C-term
同用名
TrkC; NT-3 Growth Factor Receptor; NTRK3; TRKC
分子量

110-120 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

TrkC Protein, Human (HEK293, His-Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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