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  4. UROD 蛋白, Human (His)

UROD 蛋白, Human (His)

目录号: HY-P71080
产品使用指南

UROD 蛋白催化尿卟啉原乙酸侧链的连续脱羧形成粪卟啉原，并有助于血红素生物合成途径的第五步。UROD 蛋白, Human (His) 是重组的 UROD 蛋白，由 E. coli 表达，带有 N-6*His 标签。UROD 蛋白, Human (His) 全长 367 个氨基酸，分子量约为 ~40.0 kDa。

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描述

UROD proteins catalyze the sequential decarboxylation of the acetate side chain of uroporphyrinogen to form coproporphyrinogen and contribute to the fifth step of the heme biosynthetic pathway. UROD Protein, Human (His) is the recombinant human-derived UROD protein, expressed by E. coli , with N-6*His labeled tag. The total length of UROD Protein, Human (His) is 367 a.a., with molecular weight of ~40.0 kDa.
研究背景

UROD蛋白在血红素生物合成途径中发挥着至关重要的作用，它催化尿卟啉原的四个乙酸侧链依次脱羧，导致粪卟啉原的形成。尿卟啉原异构体I和异构体III均可作为底物，但只有粪卟啉原III可以进一步转化为血红素。这种酶促过程代表了血红素生物合成的第五步，对于产生这种参与各种生理功能的关键成分至关重要。此外，体外实验证明 UROD 能够使五羧酸卟啉原 I 脱羧，强调其底物特异性的多功能性。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

P06132 (M1-N367)
基因 ID
蛋白结构
N-term
6*His
UROD (M1-N367)
Accession # P06132
C-term
同用名
Uroporphyrinogen Decarboxylase; UPD; URO-D; UROD
氨基酸序列

MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN

分子量

Approximately 40.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

UROD Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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