VEGF-DD 蛋白, Mouse (HEK293, Fc)

VEGF-DD Protein, a versatile growth factor, orchestrates angiogenesis, lymphangiogenesis, and endothelial cell growth. It stimulates proliferation, migration, and influences vessel permeability. VEGF-DD binds VEGFR-3, triggering crucial signaling for vascular development. Structurally, VEGF-DD is a non-covalent homodimer, emphasizing its intricate role in vascular processes. VEGF-DD Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VEGF-DD protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-DD Protein, Mouse (HEK293, Fc) is 109 a.a., with molecular weight of ~45 & 36 kDa, respectively.

VEGF-DD 是一种多功能生长因子，通过协调增殖、迁移和影响血管通透性等过程，在血管生成、淋巴管生成和内皮细胞生长中发挥关键作用。它的参与跨越关键阶段，有助于胚胎发生过程中静脉和淋巴管系统的形成，并维持成人分化的淋巴管内皮的完整性。在功能上，VEGF-DD 结合并激活 VEGFR-3 (Flt4) 受体，启动血管发育和稳态的重要信号级联。在结构上，VEGF-DD 以同二聚体形式存在，其特征是非共价和反平行构型，强调了其在协调复杂血管现象中的复杂作用。

Measured by its ability to inhibit the proliferation of HUVEC cells. The ED₅₀ for this effect is 0.3018 μg/mL, corresponding to a specific activity is 3.313×10⁴ U/mg.

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  Measured by its ability to inhibit the proliferation of HUVEC cells. The ED₅₀ for this effect is 0.3018 μg/mL, corresponding to a specific activity is 3.313×10⁴U/mg.

Mouse

HEK293

N-hFc

P97946 (F98-S206)

14205  [NCBI]

FYDTETLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRCGGCCNEEGVMCMNTSTSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYS

Approximately 42-50 kDa, due to glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.