VSIG4 蛋白, Mouse (HEK293, His-Fc)

V-set and immunoglobulin domain containing 4 (Vsig4) is a membrane protein belonging to complement receptor of the immunoglobulin superfamily. Vsig4 may be a negative regulator of T-cell responses and interleukin-2 production, Vsig4 also mediates clearance of C3b opsonized pathogens by binding C3b. The expression of VSIG4 is restricted to tissue macrophages where Vsig4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. VSIG4 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived VSIG4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

V-系含免疫球蛋白结构域蛋白 4 (Vsig4) 是属于免疫球蛋白超家族补体受体的膜蛋白。Vsig4 在结构上与免疫调节蛋白 B7 家族相关。
Vsig4 可能是 T 细胞反应、白细胞介素 2 产生的负调节因子，也是补体成分 3 片段 C3b 和 iC3b 的受体。通过结合 C3b，VSIG4 介导清除 C3b 调理的病原体，例如单核细胞增生李斯特菌和金黄色葡萄球菌。
VSIG4的表达仅限于组织巨噬细胞，包括腹膜巨噬细胞和肝脏 Kupffer 细胞。此外，VSIG4 标志着与糖尿病抵抗相关的巨噬细胞亚群。
VSIG4 通过刺激 PI3K/Akt-STAT3 级联、增强丙酮酸脱氢酶激酶 2 (PDK2) 的表达以及通过磷酸化抑制丙酮酸脱氢酶 (PDH) 活性来拮抗巨噬细胞中的激活信号。因此，VSIG4 在氧化磷酸化过程中限制线粒体中的丙酮酸代谢，从而抑制 mtROS 分泌和 M1 分化^[1][2]。

Mouse

HEK293

C-hFc;C-His

F6TUL9 (H20-P187)

278180  [NCBI]

Approximately 60 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.