2. Apoptosis
  3. RIP kinase
  4. RIPK1-IN-11

RIPK1-IN-11是一种口服有效的RIPK1抑制剂 (Kd=9.2 nM; IC50=67 nM)，可抑制人和小鼠细胞坏死。具有抗炎活性。

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RIPK1-IN-11 Chemical Structure

RIPK1-IN-11 Chemical Structure

CAS No. : 2173557-02-1

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RIPK1-IN-11 相关抗体

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RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM). RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM). Anti-inflammatory activity[1].

体外研究
(In Vitro)

RIPK1-IN-11 (compound 70) (24 hours; for 1h prior to the treatment of TNFα) efficiently blocks necroptosis induced by TNFα in both human and mouse cells (EC50=17-30 nM)[1].
Pharmacokinetic profiles of compound 70 in male SD rats

IV (2 mg/kg) PO (10 mg/kg)
Tmax (h) 1.2
Cmax (ng/mL) 1330 1241
AUC0-24 (ng/mL∗h) 1208 3827
t1/2 (ng/mL) 1.0 1.7
CL (mL/min/kg) 33
Vd, ss (L/kg) 2.4
F (%) 63%

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RIPK1-IN-11 相关抗体:
体内研究
(In Vivo)

RIPK1-IN-11 (3 mg/kg; i.p. for 30 min, followed by injection with TNFα) blocks hypothermia and death in mice in the TNFα-induced SIRS model[1].
RIPK1-IN-11 (5 mg/kg, 25 mg/kg; p.o.; 7 days; C57BL/6 mouse) exhibits no obvious toxicity in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice (TNF-induced systemic inflammatory response syndrome)[1]
Dosage: 3 mg/kg
Administration: i.p. for 30 min, followed by injection with TNFα (0.25 μg/g)
Result: Significantly reduced TNFα-induced temperature loss and ameliorated lethal shock in mice.
分子量

452.53

Formula

C23H24N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIPK1-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-112173557-02-1RIP kinaseReceptor-interacting protein kinasesRIPKnecroptosisRIPK1 kinaseinflammatoryTNFαanti-inflammatory activitytoxicityInhibitorinhibitorinhibit

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目录号：
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