2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. TrkB-IN-1

TrkB-IN-1 是一种有效的具有口服活性的 TrkB 激动剂，具有良好的药代特性。TrkB-IN-1 逆转 AD 小鼠模型中的认知缺陷，可用于阿尔茨海默病研究。

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TrkB-IN-1 Chemical Structure

TrkB-IN-1 Chemical Structure

CAS No. : 1609067-49-3

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TrkB-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties. TrkB-IN-1 reverses the cognitive defects in an AD mouse model and can be used for alzheimer’s disease research[1].

IC50 & Target[1]

TrkB

 

体内研究
(In Vivo)

TrkB-IN-1 (oral gavage; 7.25 mg/kg, 21.8 mg/kg, 43.6 mg/kg; 3 month) 在 5XFAD 小鼠中以剂量依赖性方式激活小鼠海马中的 TrkB 信号级联，p-TrkB/TrkB、p-Akt/Akt 和 p-ERK/ERK 的比值也增加[1]。
TrkB-IN-1 (oral gavage; 7.25 mg/kg, 21.8 mg/kg, 43.6 mg/kg; 5 days) 可减轻 5XFAD 小鼠的 Aβ 沉积并恢复记忆缺陷[1]。
TrkB-IN-1 (oral gavage; 36 mg/kg) 的口服生物利用度为 10.5%，Cmax 为 129 ng/mL, Tmax 为 0.5 h, T1/2 为 3.66 h[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

368.34

Formula

C19H16N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TrkB-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrkB-IN-11609067-49-3Trk ReceptorTropomyosin related kinase receptorProdrugpharmacokineticsTrkBAlzheimer’s diseaseADagonistcognitive defectInhibitorinhibitorinhibit

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