Tubulin/HDAC-IN-3 

Tubulin/HDAC-IN-3 (compound 12a) is a potent tubulin/HDAC dual inhibitor. Tubulin/HDAC-IN-3 effectively disrupts tubulin polymerization (IC₅₀: 5.4 μM). Tubulin/HDAC-IN-3 exhibits potent HDAC1/8 inhibitory activities, with IC₅₀ values of 0.155 and 0.177 μM, respectively. Tubulin/HDAC-IN-3 works through blocking cellular cycle, inducing apoptosis and inhibiting colony formation^[1].

Tubulin/HDAC-IN-3 (compound 12a) 在体外对四种肿瘤细胞系 (BE-(2)-C、A549、U87MG 和 HCT116) 显示出抗增殖活性，IC₅₀ 值为 0.017 分别为 ±0.002、0.053±0.003、0.056±0.005 和 0.051±0.003 μM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin/HDAC-IN-3 (compound 12a) (25 mg/kg，每三天腹腔注射)在小鼠中表现出显着的抗肿瘤功效^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

552.53

C₂₈H₂₈N₂O₁₀

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tang H, et al. Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity. Bioorg Med Chem. 2023 Sep 7;92:117437.  [Content Brief]