2. Immunology/Inflammation
  3. STING
  4. Ulevostinag

Ulevostinag  (Synonyms: MK-1454)

目录号: HY-139586
COA 产品使用指南

摩尔计算器

Ulevostinag (MK-1454) 是一种强效的干扰素基因刺激蛋白 (STING) 的环二核苷酸激动剂。Ulevostinag (MK-1454) 在肿瘤内途径通过靶向干扰素基因刺激蛋白 (STING) 蛋白起作用。Ulevostinag (MK-1454) 可用于免疫肿瘤癌症相关疾病的研究。

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Ulevostinag Chemical Structure

Ulevostinag Chemical Structure

CAS No. : 2082743-96-0

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规格 价格 是否有货
1 mg ￥12000
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Ulevostinag 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research[1].

体内研究
(In Vivo)

Ulevostinag (MK-1454) (5 μg, 20 μg, 瘤内注射) 可以激活 MC38 注射肿瘤的肿瘤特异性免疫反应，并抑制未治疗的远端肿瘤生长[1]。
Ulevostinag (MK-1454) (4 μg, 在第 0, 3 和 7天进行瘤内注射) 使 MC38 和 B16F10 肿瘤小鼠模型的肿瘤完全消退，并增强抗 PD1 治疗的效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 colon adenocarcinoma tumor-bearing mice[1]
Dosage: 5 μg, 20 μg
Administration: intratumorally
Result: Regressed the injected (right) tumors and was detected in injected and noninjected tumors as well as plasma when dosed at 20 μg.
Elevated IFN-β and proinflammatory cytokines IL-6 and TNF-α in injected tumors.
Animal Model: MC38 and B16F10 tumor mice model[1]
Dosage: 4 μg
Administration: intratumorally
Result: Improved tumor growth inhibition with 7 CRs out of 10 mice over 28 days.
Clinical Trial
分子量

710.52

Formula

C20H22F2N10O9P2S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Ulevostinag 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ulevostinag2082743-96-0MK-1454MK1454MK 1454STINGStimulator of Interferon GenesTMEM173MITAERISMPYStumorInhibitorinhibitorinhibit

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目录号：
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