1. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  2. ATM/ATR
  3. WSD0628

WSD0628 是可透过血脑屏障的,有效的 ATM 抑制剂,具有明显的放射增敏效果。

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WSD0628 Chemical Structure

WSD0628 Chemical Structure

CAS No. : 2765448-96-0

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货
1 mg ¥2000
询问价格 & 货期
5 mg ¥5100
询问价格 & 货期
10 mg 现货 询问价格 & 货期
25 mg 现货 询问价格 & 货期

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Customer Review

查看 ATM/ATR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect[1].

体外研究
(In Vitro)

WSD0628 significantly increased the radiosensitivity of U251 cells in clonogenic survival assays (0 nM vs. 30 nM at 5Gy, p<0.01)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

WSD0628 (10 mg/kg, a single dose of 12.5 Gy combined) has profound impact on treatment efficacy in the melanoma brain metastasis M12 PDX[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

439.46

Formula

C23H23F2N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
WSD0628
目录号:
HY-162002
需求量: