2. 天然产物
  3. 植物 萜类
  4. 茄科 二萜
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  6. β-Cembrenediol

β-Cembrenediol 是一种有效的具有口服活性的抗癌剂。β-Cembrenediol 具有植物毒性。β-Cembrenediol 可减少细胞迁移和菌落形成。β-Cembrenediol 可降低 TDO2、IDO1 的蛋白表达。β-Cembrenediol 具有用于前列腺癌研究的潜力。

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β-Cembrenediol Chemical Structure

β-Cembrenediol Chemical Structure

CAS No. : 57605-81-9

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β-Cembrenediol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer[1][2].

体外研究
(In Vitro)

β-Cembrenediol (25、50、100、200 µg/mL) 以剂量依赖性方式抑制生菜幼苗茎长和根长[1]。
β-Cembrenediol (0、0.2、0.5、1、5、10 µM) 以剂量依赖性方式减少迁移和菌落形成[2]。
β-Cembrenediol (5、10、20 µM；48 小时) 以剂量依赖性方式降低 TDO2、IDO1 的蛋白质表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Cembrenediol 相关抗体:

Western Blot Analysis[2]

Cell Line: PC-3M cells
Concentration: 5, 10, 20 µM
Incubation Time: 48 h
Result: Decreased the protein expression of TDO2, IDO1 in a dose-dependent manner.
体内研究
(In Vivo)

β-Cembrenediol (15 mg/kg; p.o.; daily for 8 weeks) 对前列腺癌小鼠表现出抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice (PC-3M PC cells)[2]
Dosage: 15 mg/kg
Administration: P.o.; daily for 8 weeks
Result: Significantly suppressed the development, extended the latency, and delayed the onset of the locoregional PC-3M cell tumor recurrence, reduced mice plasma total prostate-specific antigen and plasma kynurenine level.
分子量

306.48

Formula

C20H34O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Cembrenediol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Cembrenediol57605-81-9Othersorally activePC-3M cellsTDO2IDO1prostate cancerInhibitorinhibitorinhibit

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