2. 天然产物
  3. 疾病研究领域 海洋天然产物 黄酮类 微生物
  4. 心血管 海洋微生物 其他黄酮类
  5. 2,3,4,6,8-Pentahydroxy-1-methylxanthone

2,3,4,6,8-Pentahydroxy-1-methylxanthone 

目录号: HY-N12166
产品使用指南

摩尔计算器

2,3,4,6,8-Pentahydroxy-1-methylxanthone 是 Wardomyces anomalus 的山酮衍生物。2,3,4,6,8-Pentahydroxy-1-methylxanthone 具有显著的抗氧化活性。2,3,4,6,8-Pentahydroxy-1-methylxanthone 是 p56lck 酪氨酸激酶抑制剂。2,3,4,6,8-Pentahydroxy-1-methylxanthone 能够用于治疗心血管疾病的研究。

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2,3,4,6,8-Pentahydroxy-1-methylxanthone Chemical Structure

2,3,4,6,8-Pentahydroxy-1-methylxanthone Chemical Structure

CAS No. : 548740-87-0

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2,3,4,6,8-Pentahydroxy-1-methylxanthone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to treat cardiovascular disease[1].

IC50 & Target

p56 lck[1]
体外研究
(In Vitro)

2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞对 ox-LDL 诱导的细胞凋亡具有保护作用[2]。
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞抑制 ox-LDL 诱导的 VECs粘附分子表达[2]。
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞对ox-LDL 引起的氧化损伤有保护作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2,3,4,6,8-Pentahydroxy-1-methylxanthone 相关抗体:

Apoptosis Analysis[2]

Cell Line: Human umbilical vein endothelial cells
Concentration: 1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time: 6h
Result: The percentage of apoptosis cells significantly decreased to around 20 ~ 40%.

Western Blot Analysis[2]

Cell Line: Human umbilical vein endothelial cells
Concentration: 1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time: 6h
Result: The level of pro-apoptotic protein Bax decreased significantly, while that of anti-apoptotic protein Bcl-2 increased significantly.

Apoptosis Analysis[2]

Cell Line: Human umbilical vein endothelial cells
Concentration: 1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time: 6h
Result: The protein level of VCAM-1 and ICAM-1 decreased.

Immunofluorescence[2]

Cell Line: Human umbilical vein endothelial cells
Concentration: 1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time: 6h
Result: Activated Nrf2 nuclear translocations and the expression of HO-1 was significantly increased.
分子量

290.23

Formula

C14H10O7
CAS 号
结构分类
初始来源

Arthrinium sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2,3,4,6,8-Pentahydroxy-1-methylxanthone 相关分类

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Keywords:

2,3,4,6,8-Pentahydroxy-1-methylxanthone548740-87-0OthersHUVECsNtioxidantApoptosisInhibitorinhibitorinhibit

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