2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Virus Protease
  4. 2'-Deoxy-2'-fluoro-l-uridine

2'-Deoxy-2'-fluoro-l-uridine 是 L-核苷类化合物。2'-Deoxy-2'-fluoro-l-uridine 是一种有效的选择性病毒 RNA 聚合酶抑制剂，从而抑制 RNA 病毒的复制。

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2'-Deoxy-2'-fluoro-l-uridine Chemical Structure

2'-Deoxy-2'-fluoro-l-uridine Chemical Structure

CAS No. : 622785-69-7

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2'-Deoxy-2'-fluoro-l-uridine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEp-2 EC50
> 100 μM
Compound: 2'd2'FU
Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
[PMID: 25978965]
HEp-2 IC50
3.5 μM
Compound: 2'd2'FU
Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
[PMID: 25978965]
分子量

246.19

Formula

C9H11FN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2'-Deoxy-2'-fluoro-l-uridine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxy-2'-fluoro-l-uridine622785-69-7DNA/RNA SynthesisVirus ProteaseL-nucleoside compoundRNA polymeraseRNA virus replicationInhibitorinhibitorinhibit

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