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  4. 5-DACTHF

5-DACTHF  (Synonyms: 543U76; 5,11-Methenyltetrahydrohomofolate)

目录号: HY-14526
产品使用指南

摩尔计算器

5-DACTHF (543U76) 是嘌呤从头生物合成的抑制剂。5-DACTHF 是一种 GAR-TFase 和 AICAR-TFase 抑制剂 (IC50 分别为 3 和 94 μM) 。5-DACTHF 是一种有效的抗肿瘤剂。

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5-DACTHF Chemical Structure

5-DACTHF Chemical Structure

CAS No. : 118252-44-1

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5-DACTHF 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
0.037 μM
Compound: 1
In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
[PMID: 1573633]
分子量

432.43

Formula

C19H24N6O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-DACTHF 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-DACTHF118252-44-1543U76 5,11-MethenyltetrahydrohomofolateOtherspurine biosynthesisantitumorMCF-7MOLT-4 cellsInhibitorinhibitorinhibit

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