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  4. (5R)-5-Hydroxytriptolide

(5R)-5-Hydroxytriptolide  (Synonyms: PG 701; LLDT-8; 5α-Hydroxytriptolide)

目录号: HY-107101
产品使用指南

摩尔计算器

(5R)-5-Hydroxytriptolide 是从雷公藤中提取的化合物，具有较低的细胞毒性和较高的免疫抑制活性。(5R)-5-Hydroxytriptolide 可用于类风湿关节炎的研究。

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(5R)-5-Hydroxytriptolide Chemical Structure

(5R)-5-Hydroxytriptolide Chemical Structure

CAS No. : 583028-68-6

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规格 价格 是否有货 数量
1 mg ￥6000
4 - 5 周
5 mg 现货 4 - 5 周
10 mg   询价  
50 mg   询价  

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Customer Review

(5R)-5-Hydroxytriptolide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.04 nM
Compound: 7; LLDT-8
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 31121546]
BGC-823 IC50
1.5 μM
Compound: 7; LLDT-8
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
[PMID: 31121546]
HeLa IC50
0.34 μM
Compound: 7; LLDT-8
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
[PMID: 31121546]
HL-60 IC50
0.04 nM
Compound: 7; LLDT-8
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 31121546]
HL-60 IC50
0.47 μM
Compound: 7; LLDT-8
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
[PMID: 31121546]
KB IC50
0.3 μM
Compound: 7; LLDT-8
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
[PMID: 31121546]
MCF7 IC50
0.04 nM
Compound: 7; LLDT-8
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 31121546]
MCF7 IC50
1.05 μM
Compound: 7; LLDT-8
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
[PMID: 31121546]
MKN-28 IC50
0.04 nM
Compound: 7; LLDT-8
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 31121546]
P388 IC50
0.04 nM
Compound: 7; LLDT-8
Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 31121546]
PC-3 IC50
0.275 μM
Compound: 4
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
[PMID: 25467158]
U-251 IC50
0.488 μM
Compound: 4
Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
[PMID: 25467158]
分子量

376.40

Formula

C20H24O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(5R)-5-Hydroxytriptolide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(5R)-5-Hydroxytriptolide583028-68-6PG 701 LLDT-8 5α-HydroxytriptolidePG701PG-701LLDT8LLDT 8LLDT-8OthersTripterygiumrheumatoid arthritisperipheral blood mononuclear cellInhibitorinhibitorinhibit

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