2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Becampanel

Becampanel (AMP397) 是有效的 AMPA 拮抗剂，也是一种抗癫痫药。

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Becampanel Chemical Structure

Becampanel Chemical Structure

CAS No. : 188696-80-2

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Becampanel 相关抗体

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查看 iGluR 亚型特异性产品:

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.

体外研究
(In Vitro)

Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Becampanel 相关抗体:
体内研究
(In Vivo)

Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

330.19

Formula

C10H11N4O7P
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
Animal Administration
[1]

The study protocol is in compliance with the corresponding OECD guideline. The test article is dissolved in 0.2 M NaHCO3. The dose-finding experiment with Becampanel shows that treatment of CD-1 mice by oral gavage with 450.5, 500 or 800 mg/kg, twice with an interval of 24 h, leads to strong signs of toxicity such as laboured breathing, ataxia, and strong sedation. At 320 mg/kg, the same symptoms are visible, but with less severity, and no animals die. On the basis of these results, doses of 32, 100 and 320 mg/kg are chosen for this micronucleus test. In the main experiment five male and five female mice are treated as described above and bone marrow is sampled 48 h after the first application. Nucleated cells are removed from the bone marrow samples using cellulose columns. The cells are loaded on poly-l-lysine coated glass slides by cytocentrifugation using a Shandon Cytospin stained with May Grunwald stain (5%) and Giemsa (14%). The slides are automatically evaluated with a LEITZ MIAS image analyser. No statistical analysis is performed since all values in the treated groups are≤the frequency of micronucleated polychromatic erythrocyte in the concurrent vehicle control group.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Becampanel 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Becampanel188696-80-2AMP 397AMP397AMP-397iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
Becampanel
目录号：
HY-15073
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