2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Wee1

Wee1 (Wee1蛋白激酶)

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G2/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.

Wee1 相关产品 (36):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145666
    Myt1-IN-3 Inhibitor 99.14%
    Myt1-IN-3 是一种有效的 Myt1 抑制剂，IC50 小于 10 nM (WO2021195782 A1, compound 95)。
    Myt1-IN-3
  • HY-145665
    Myt1-IN-2 Inhibitor
    Myt1-IN-2 是一种有效的 Myt1 抑制剂，IC50 <10 nM。Myt1-IN-2 具 有抗癌作用。
    Myt1-IN-2
  • HY-163491
    PKMYT1-IN-2 Inhibitor
    PKMYT1-IN-2 (compound 2) 是一种有效的 PKMYT1 抑制剂，IC50 为 5.7 nM。PKMYT1-IN-2 抑制 HCC1569 细胞的生长，IC50 为 22 nM。
    PKMYT1-IN-2
  • HY-157443
    Myt1-IN-4 Inhibitor
    Myt1-IN-4 (21) 是具有口服活性的、选择性的 MYT1 抑制剂，其IC50 值为2.6 nM。Myt1-IN-4 (21) 具有抗肿瘤活性。
    Myt1-IN-4
  • HY-168654
    WEE1 degrader 1 Degrader
    WEE1 degrader 1 (Compound 10) 是 Wee1 降解剂，对 Wee1 的 DC50 值为 1.5 nM。WEE1 degrader 1 具有抗癌细胞增殖作用。
    WEE1 degrader 1
  • HY-160530
    WEE1-IN-6 Inhibitor
    WEE1-IN-6 (compound 110) 是一种口服活性 WEE1 抑制剂，DC50 值≤ 100 nM。WEE1-IN-6 抑制细胞增殖。
    WEE1-IN-6
  • HY-162849
    PKMYT1-IN-3 Inhibitor
    PKMYT1-IN-3 (compound 8ma) 是一种有效和选择性的 PKMYT1 抑制剂，IC50 值为 16.5 nM。PKMYT1-IN-3 具有抗肿瘤活性。
    PKMYT1-IN-3
  • HY-143342
    LEB-03-144
    LEB-03-144 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过 C3 烷基连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。LEB-03-144 在 HEP3B 肝癌细胞中可显著稳定 WEE1。
    LEB-03-144
  • HY-13925A
    PD0166285 dihydrochloride Inhibitor
    PD0166285 dihydrochloride是 P-gp 的一个底物，是 WEE1 抑制剂，也可微弱抑制 Myt1，IC50 值分别为 24 和 72 nM。PD0166285 dihydrochloride 对 Chk1 的 IC50 值为3.433 μM。
    PD0166285 dihydrochloride
  • HY-161880
    WEE1-IN-10 Inhibitor
    WEE1-IN-10 (compound 77) 是一种 Wee1 激酶抑制剂。WEE1-IN-10 对 LOVO 细胞生长有抑制活性，IC50 为 0.524 μM。WEE1-IN-10 可用于研究由 Wee1 活性异常引起的疾病。
    WEE1-IN-10
  • HY-143343
    LEB-03-153
    LEB-03-153 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过无连接剂将 AZD1775 (Adavosertib) 连接到 OTUB1 的招募者 EN523。
    LEB-03-153
  • HY-143340
    LEB-03-145
    LEB-03-145 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过 C5 烷基连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。
    LEB-03-145
  • HY-163697
    WEE1-IN-7 Inhibitor
    WEE1-IN-7 (compound 12h) 是一种有效的具有口服活性的 WEE1 抑制剂，其IC50值为 2.1 nM。WEE1-IN-7 诱导细胞凋亡 (apoptosis) 和细胞周期停滞于 S 期。WEE1-IN-7 具有抗肿瘤活性。
    WEE1-IN-7
  • HY-10993R
    Adavosertib (Standard) Inhibitor
    Adavosertib (Standard)是 Adavosertib 的分析标准品。本产品用于研究及分析应用。Adavosertib (AZD-1775; MK-1775) 是一种有效的 Wee1 抑制剂，IC50 值为 5.2 nM。
    Adavosertib (Standard)
  • HY-162986
    PKMYT1-IN-4 Inhibitor
    PKMYT1-IN-4 (compund 27) 是 PKMYT1 抑制剂，IC50 小于 50 nM。
    PKMYT1-IN-4
  • HY-162987
    PKMYT1-IN-6 Inhibitor
    PKMYT1-IN-6 (compund 98) 是 PKMYT1 抑制剂，IC50 小于 50 nM。
    PKMYT1-IN-6
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z