2. Signaling Pathways
  3. GPCR/G Protein
  4. ICMT

ICMT 

Isoprenylcysteine carboxyl methyltransferase

ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].

ICMT 相关产品 (66):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149709
    ICMT-IN-35 Inhibitor
    ICMT-IN-35 (compound 10n) 是一种 FTPA-triazole 化合物和 ICMT 抑制剂 (IC50=0.8 μM)。ICMT-IN-35 被哺乳动物细胞吸收，可阻止 K-Ras 膜定位、诱导 K-Ras 错定位。此外，ICMT-IN-35 对 ICMT+/+ MEF 细胞具有选择性的细胞毒性，并且对转移性胰腺癌细胞系具有低微摩尔活性 (IC50=0.8 μM)。
    ICMT-IN-35
  • HY-157117
    ICMT-IN-49 Inhibitor
    ICMT-IN-49 (compound 2) 是一种 ICMT 抑制剂 (IC50=0.12 μM)。
    ICMT-IN-49
  • HY-157110
    ICMT-IN-42 Inhibitor
    ICMT-IN-42 (compound 21) 是一种 ICMT 抑制剂 (IC50=0.054 μM)。
    ICMT-IN-42
  • HY-157113
    ICMT-IN-45 Inhibitor
    ICMT-IN-45 (compound 24) 是一种 ICMT 抑制剂 (IC50=0.132 μM)。
    ICMT-IN-45
  • HY-157106
    ICMT-IN-38 Inhibitor
    ICMT-IN-38 (compound 42) 是一种 ICMT 抑制剂 (IC50=0.049 μM)。
    ICMT-IN-38
  • HY-149706
    ICMT-IN-12 Inhibitor
    ICMT-IN-12 (compound 78) 是一种 ICMT 抑制剂 (IC50=0.42 μM)。
    ICMT-IN-12
  • HY-155435
    ICMT-IN-32 Inhibitor
    ICMT-IN-32 (compound 70) 是一种 ICMT 抑制剂 (IC50=0.777 μM)。
    ICMT-IN-32
  • HY-155425
    ICMT-IN-17 Inhibitor
    ICMT-IN-17 (compound 52) 是一种 ICMT 抑制剂 (IC50=0.38 μM)。
    ICMT-IN-17
  • HY-157092
    ICMT-IN-3 Inhibitor
    ICMT-IN-3 (compound 27) 是一种 ICMT 抑制剂 (IC50=0.015 μM)。
    ICMT-IN-3
  • HY-155420
    ICMT-IN-9 Inhibitor
    ICMT-IN-9 (compound 47) 是一种 ICMT 抑制剂 (IC50=0.16 μM)。
    ICMT-IN-9
  • HY-149729
    ICMT-IN-53 Inhibitor
    ICMT-IN-53 (compound 12) 是一种 ICMT 抑制剂 (IC50=0.96 μM)，具有 PAMPA 渗透性和抗增殖活性。ICMT-IN-53 抑制 MDA-MB-231 和 PC3 的增殖，IC50s 分别为 5.14 μM 和 5.88 μM。
    ICMT-IN-53
  • HY-157092A
    (S)-ICMT-IN-3 Inhibitor
    (S)-ICMT-IN-3 (compound ent 1-27) 是一种 ICMT 抑制剂 (IC50=0.23 μM)。
    (S)-ICMT-IN-3
  • HY-157107
    ICMT-IN-39 Inhibitor
    ICMT-IN-39 (compound 18) 是一种 ICMT 抑制剂 (IC50=0.031 μM)。
    ICMT-IN-39
  • HY-157109
    ICMT-IN-41 Inhibitor
    ICMT-IN-41 (compound 20) 是一种 ICMT 抑制剂 (IC50=0.069 μM)。
    ICMT-IN-41
  • HY-155418
    ICMT-IN-2 Inhibitor
    ICMT-IN-2 (compound 45) 是一种 ICMT 抑制剂 (IC50=0.168 μM)。
    ICMT-IN-2
  • HY-155426
    ICMT-IN-19 Inhibitor
    ICMT-IN-19 (compound 53) 是一种 ICMT 抑制剂 (IC50=0.026 μM)。
    ICMT-IN-19
  • HY-155423
    ICMT-IN-14 Inhibitor
    ICMT-IN-14 (compound 50) 是一种 ICMT 抑制剂 (IC50=0.025 μM)。
    ICMT-IN-14
  • HY-157099
    ICMT-IN-18 Inhibitor
    ICMT-IN-18 (compound 35) 是一种 ICMT 抑制剂 (IC50=0.066 μM)。
    ICMT-IN-18
  • HY-157100
    ICMT-IN-23 Inhibitor
    ICMT-IN-23 (compound 36) 是一种 ICMT 抑制剂 (IC50=0.123 μM)。
    ICMT-IN-23
  • HY-157095
    ICMT-IN-6 Inhibitor
    ICMT-IN-6 (compound 29) 是一种 ICMT 抑制剂 (IC50=0.09 μM)。
    ICMT-IN-6
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