2. Anti-infection Epigenetics
  3. Small Interfering RNA (siRNA) HBV
  4. AB-729 sodium

AB-729 sodium 是一种siRNA，通过RNA 干扰 (RNAi)抑制病毒复制并减少 HBV 抗原。AB-729 sodium 与 N-乙酰半乳糖胺 (GalNAc) 配体的三聚体结合，通过去唾液酸糖蛋白受体 (ASGR) 促进肝细胞摄取 。

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RNA, (Gm-sp-Um-sp-Gm-Cm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Um-Cm-Gm-Cm-Um-Um-Cm-Am-Cm-Am), 3′-[[[rel-(3S,4R)]-1-(9-carboxy-1-oxononyl)-4-(hydroxymethyl)-3,4-dimethyl-3-pyrrolidinyl]methyl hydrogen phosphate], carboxamide with L-glutamoylbis[N-[3,5-bis[[[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]ethoxy]ethoxy]ethyl]amino]carbonyl]phenyl]glycinamide], sodium salt, complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)G-sp-Um-Gm-Am-Am-GmCm-Gm-Am-Am-Gm-Um-(2′-deoxy-2′-fluoro)G-Cm-(2′-deoxy-2′-fluoro)A-Cm-Am-Cmsp-Gm-sp-Gm-U), sodium salt

AB-729 sodium Chemical Structure

CAS No. : 2826248-50-2

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AB-729 sodium 相关抗体

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  • 生物活性

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生物活性

AB-729 sodium is a siRNA specifically designed to inhibit viral replication and reduces HBV antigens[1][2]. AB-729 conjugates to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes uptake into hepatocytes via the asialoglycoprotein receptor (ASGR).

分子量

16148.44

Formula

C502H640F6N162Na38O303P38S6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AB-729 sodium 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

AB-7292826248-50-2AB729AB 729Small Interfering RNA (siRNA)HBVHepatitis B virusnucleosideRNAiN-acetylgalactosamineGalNAcASGRviralreplicationInhibitorinhibitorinhibit

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