2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Acasunlimab

Acasunlimab  (Synonyms: GEN1046)

目录号: HY-P99419 纯度: 99.90%
COA

摩尔计算器

Acasunlimab (GEN1046) 是一种双特异性抗体 (bsAb)，靶向 PD-L1 和 4-1BB。Acasunlimab 通过有条件的 4-1BB 刺激增强 T 细胞和 NK 细胞功能，同时构成性地阻断 PD-1/PD-L1 抑制轴。Acasunlimab 可用于癌症的研究。

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CAS No. : 2253937-12-9

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规格 价格 是否有货 数量
1 mg ￥7500
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5 mg   询价  
10 mg   询价  

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Acasunlimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer[1][2].

同型

Ig(G1-kappa_G1-lambda2)
种属

Humanized
体外研究
(In Vitro)

Acasunlimab (GEN1046; 0.001-1 μM; 0-525 min) 促进树突状细胞和 T 细胞之间的相互作用并增强 T 细胞活化[1]。
Acasunlimab (0.001-1 μM; 48 h; PD-L1+ Tumor Cells) 在体外诱导剂量依赖性、条件性 T 细胞增殖和细胞因子产生，并增强抗原特异性 T 细胞介导的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acasunlimab 相关抗体:
体内研究
(In Vivo)

Acasunlimab (5 mg/kg; i.v.; 每周两次，共三个周期) 在双敲入 (dKI) 转基因 C57BL/6 小鼠中具有抗肿瘤活性并抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Double knock-in (dKI) transgenic C57BL/6 mice[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; twice weekly for three cycles
Result: Had antitumor activity in double knock-in (dKI) transgenic C57BL/6 mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Ig(G1-kappa_G1-lambda2)
Biological Activity
  • Immobilized Human 4-1BB/CD137 Protein (ECD, His Tag) can bind Acasunlimab. The EC50 for this effect is 5.74 ng/mL.
  • Immobilized Human PD-L1/B7-H1 Protein (ECD) can bind Acasunlimab. The EC50 for this effect is 11.27 ng/mL.
纯度 & 产品资料
参考文献

Acasunlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acasunlimab2253937-12-9GEN1046GEN 1046GEN-1046PD-1/PD-L1PD-1/Programmed death-ligand 1T-cellNK-cellPD-1/PD-L1 inhibitory axiscancerdendritic cellsInhibitorinhibitorinhibit

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