2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Androgen receptor antagonist 7

Androgen receptor antagonist 7 

目录号: HY-152524
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Androgen receptor antagonist 7 是一种有效的雄激素受体 (androgen receptor (AR)) 拮抗剂，IC50 值为 1.18 µM。Androgen receptor antagonist 7 具有体外生物活性并以时间和剂量依赖的方式抑制 AR 靶的表达，GI50 值为 7.9 µM。

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Androgen receptor antagonist 7 Chemical Structure

Androgen receptor antagonist 7 Chemical Structure

CAS No. : 2409791-89-3

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Androgen receptor antagonist 7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Androgen receptor antagonist 7 is an effective androgen receptor (AR) antagonist with an IC50 value of 1.18 µM. Androgen receptor antagonist 7 has biological activity in vitro and inhibits the expression of AR target in a time and dose dependent manner with an GI50 value of 7.9 µM [1].

IC50 & Target

IC50: 1.18 µM[1]
体外研究
(In Vitro)

Androgen receptor antagonist 7 (compound 3d) (10 µM；24 h) 显著降低 AR 蛋白表达水平[1]。
Androgen receptor antagonist 7 (20 µM；72 h) 抑制 LAPC-4 和 22Rv1 细胞的增值[1]。
Androgen receptor antagonist 7 (0-20 µM；24、48 和 72 h) 以时间和剂量依赖的方式抑制 AR 的表达，但不诱导细胞凋亡[1]。
Androgen receptor antagonist 7 (10 µM；3 d) 在体外靶向 AR 并降低 AR 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Androgen receptor antagonist 7 相关抗体:

Western Blot Analysis[1]

Cell Line: LAPC-4 cell.
Concentration: 0-20 µM.
Incubation Time: 24, 48 and 72 h.
Result: Showed inhibitory effect.

Cell Viability Assay[1]

Cell Line: LAPC-4 and 22Rv1 cells.
Concentration: 20 µM.
Incubation Time: 72 h.
Result: Showed antiproliferative effect (cell viability < 40 %).
分子量

422.58

Formula

C27H35FN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androgen receptor antagonist 7 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Androgen receptor antagonist 72409791-89-3Androgen receptor antagonist7Androgen receptor antagonist-7Androgen ReceptorLAPC-4 cellInhibitorinhibitorinhibit

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