2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 14

Anticancer agent 14 是一种先导化合物（IC50: 0.20 to 0.65 μM），可诱导乳腺癌细胞凋亡、细胞周期阻滞和线粒体膜电位丧失。

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Anticancer agent 14 Chemical Structure

Anticancer agent 14 Chemical Structure

CAS No. : 2762698-14-4

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Anticancer agent 14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 14 is a lead compound (IC50: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LA7 IC50
0.19 μM
Compound: 13d; 13d-f
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34726897]
LA7 IC50
0.24 μM
Compound: 13d; 13d-f
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 34726897]
LA7 IC50
0.66 μM
Compound: 13d; 13d-f
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 34726897]
MCF-10A IC50
> 18 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34726897]
MCF-10A IC50
> 25 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 34726897]
MCF7 IC50
0.2 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 34726897]
MCF7 IC50
0.25 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34726897]
MCF7 IC50
0.3 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 34726897]
MDA-MB-231 IC50
0.65 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 34726897]
MDA-MB-231 IC50
0.7 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 34726897]
MDA-MB-231 IC50
0.7 μM
Compound: 13d; 13d-f
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34726897]
分子量

458.59

Formula

C29H34N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 142762698-14-4Anticancer agent14Anticancer agent-14ApoptosisInhibitorinhibitorinhibit

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