1. Stem Cell/Wnt
  2. β-catenin
  3. Antitumor agent-172

Antitumor agent-172 (Compound 28) 是 β-catenin/BCL9 相互作用的抑制剂,IC50 为 3.92 μM。Antitumor agent-172 对 β-catenin 具有高亲和力,Kd 为 82 nM。Antitumor agent-172 可激活 T 细胞、促进抗原呈递,并在小鼠模型中表现出抗肿瘤活性和良好的药代动力学特征。

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Antitumor agent-172 Chemical Structure

Antitumor agent-172 Chemical Structure

CAS No. : 3027905-74-1

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  • 生物活性

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生物活性

Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with Kd of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].

IC50 & Target

Kd: 82 nM (β-catenin)
IC50: 3.92 μM (β-catenin/BCL9 interaction)

分子量

670.84

Formula

C37H50N8O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antitumor agent-172
目录号:
HY-163768
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