2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-56

Antitumor agent-56 (Compound 33) 是一种具有抗肿瘤、抗炎和 NO 释放活性的 triptolide 衍生物。Antitumor agent-56 显著抑制黑色素瘤的生长，具有口服活性。

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Antitumor agent-56 Chemical Structure

Antitumor agent-56 Chemical Structure

CAS No. : 2411579-53-6

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Antitumor agent-56 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16-F10 IC50
0.021 μM
Compound: 33
Antiproliferative activity against human B16-F10 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human B16-F10 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 32028140]
BGC-823 IC50
0.95 μM
Compound: 33
Antiproliferative activity against human BGC-823 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 32028140]
HCT-116 IC50
0.034 μM
Compound: 33
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 32028140]
HepG2 IC50
0.95 μM
Compound: 33
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 32028140]
NCI-H1650 IC50
1.57 μM
Compound: 33
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 32028140]
RAW264.7 IC50
0.086 μM
Compound: 33
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
[PMID: 32028140]
RAW264.7 IC50
0.117 μM
Compound: 33
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
[PMID: 32028140]
分子量

584.59

Formula

C28H28N2O10S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-56 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-562411579-53-6Antitumor agent56Antitumor agent 56Apoptosismelanomaanti-inflammatory activityNO releasingantitumorHCT-116HepG2BGC-823NCI-H1650B16F10Inhibitorinhibitorinhibit

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