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  4. Antitumor agent-F10

Antitumor agent-F10 (Compound F10) 是喜树碱衍生物。Antitumor agent-F10 是一种口服生物可利用的强效抗肿瘤剂。Antitumor agent-F10 的急性毒性低于SN-38，F10的溶解度达到 9.86 μg/mL。

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Antitumor agent-F10 Chemical Structure

Antitumor agent-F10 Chemical Structure

CAS No. : 2371727-65-8

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Antitumor agent-F10 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-F10 (Compound F10) is a camptothecin derivative. Antitumor agent-F10 is an orally–bioavailable and potent antitumor agent. Antitumor agent-F10 displays lower acute toxicity than SN-38 does and the solubility of F10 reached 9.86 μg/mL[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.011 μM
Compound: F10
Cytotoxicity against human A549 assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human A549 assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
COLO 205 IC50
0.096 μM
Compound: F10
Cytotoxicity against human COLO 205 assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human COLO 205 assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
HCT-116 IC50
0.003 μM
Compound: F10
Cytotoxicity against human HCT-116 assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
HeLa IC50
0.125 μM
Compound: F10
Cytotoxicity against human Hela assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Hela assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
LoVo IC50
0.081 μM
Compound: F10
Cytotoxicity against human LoVo assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human LoVo assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
NCI-H1975 IC50
0.084 μM
Compound: F10
Cytotoxicity against human NCI-H1975 assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
Raji IC50
0.002 μM
Compound: F10
Cytotoxicity against human Raji assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Raji assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32650182]
分子量

517.57

Formula

C29H31N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-F10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-F102371727-65-8Otherscamptothecin derivativeorally–bioavailableantitumor agentlower acute toxicityInhibitorinhibitorinhibit

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