2. Apoptosis Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease MAPK/ERK Pathway
  3. Atg8/LC3 p62 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase
  4. Astin B

Astin B 是一种口服有效的环状五肽，可从 Aster tataricus 中分离得到。Astin B 在体外和体内均具有肝毒性作用，肝损伤主要由线粒体/半胱天冬酶依赖性方式的细胞凋亡 (apoptosis) 介导。Astin B 在 L-02 细胞中诱导自噬 (autophagy)，增加 LC3-II 并降低 p62 表达。

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Astin B Chemical Structure

Astin B Chemical Structure

CAS No. : 151201-76-2

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Astin B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].

IC50 & Target

Bcl-2

 

Bax

 

Caspase-3

 

Caspase-9

 

体外研究
(In Vitro)

Astin B (0-60 μM, 12-48 h) 抑制 L-02 细胞的增殖[1]。
Astin B (0-60 μM, 24 h) 诱导氧化应激和线粒体功能障碍，调节 Bcl-2/Bax 表达并增加 caspase-3 和 -9 活性[1]。
Astin B (0-60 μM, 24 h) 在 L-02 细胞中诱导自噬以防止细胞凋亡[1]。
Astin B 在肝细胞中引起氧化应激相关炎症，活性氧 (ROS) 水平升高、细胞内谷胱甘肽 (GSH) 含量降低以及 c-Jun 氨基末端激酶 (JNK) 磷酸化增强得到证实[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Astin B 相关抗体:
体内研究
(In Vivo)

Astin B (10 mg/kg，口服，每天一次，连续 7 天) 诱导小鼠肝损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (6–8 weeks of age, 10 per group)[1]
Dosage: 10 mg/kg
Administration: Orally administered, once daily for 7 consecutive days
Result: Induced liver injury in mice. Compared to the control group, the serum levels of ALT and AST in mice treated with astin B were elevated about 11.9 and 2.26 times, respectively.
分子量

586.46

Formula

C25H33Cl2N5O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Astin B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astin B151201-76-2Atg8/LC3p62ApoptosisAutophagyReactive Oxygen SpeciesJNKBcl-2 FamilyCaspaseAutophagy-related 8Sequestosome-1SQSTM1c-Jun N-terminal kinaseLiver injuryAster tataricusL-02 cellslactate dehydrogenaseLDHInhibitorinhibitorinhibit

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