2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Bis-PEG8-acid

Bis-PEG8-acid 是一种 PROTAC linker，属于 PEG 类。Bis-PEG8-acid 可用于合成一系列 PROTAC 分子。Bis-PEG8-acid 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联活性分子 (ADCs) 的合成。

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Bis-PEG8-acid Chemical Structure

Bis-PEG8-acid Chemical Structure

CAS No. : 1246189-43-4

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Bis-PEG8-acid 相关抗体

Top Publications Citing Use of Products

查看 PROTAC Linkers 亚型特异性产品:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

查看 ADC Linker 亚型特异性产品:

查看所有亚型
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Cleavable Linker

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG8-acid 相关抗体:
分子量

470.51

Formula

C20H38O12
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

COA (276 KB) HNMR (113 KB) MS (73 KB)

产品使用指南 (1538 KB)
参考文献

Bis-PEG8-acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG8-acid1246189-43-4PROTAC LinkersADC LinkerAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteincleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-126893
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