2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. BMS-823778 hydrochloride

BMS-823778 hydrochloride 是一种有效的、选择性的、具有口服活性的 11β-HSD1 抑制剂，对人 11β-HSD1 的 IC50 为 2.3 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

BMS-823778 hydrochloride Chemical Structure

BMS-823778 hydrochloride Chemical Structure

CAS No. : 1140898-87-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of BMS-823778 hydrochloride:

BMS-823778 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against human 11β-HSD1[1].

IC50 & Target

IC50: 2.3 nM (human 11β-HSD1), 600 nM (mouse 11β-HSD1)[1]
Ki: 0.9 nM (human 11β-HSD1), 380 nM (mouse 11β-HSD1)[1]
体内研究
(In Vivo)

BMS-823778 (10-100 mg/kg; oral; once) hydrochloride 在饮食诱导肥胖 (DIO) 小鼠中表现出强烈的急性药效学作用 (ED50=34 mg/kg)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) mice[1]
Dosage: 10-100 mg/kg
Administration: Oral, once
Result: Inhibition of 11β-HSD-1 was observed as a measure of decrease in the plasma concentration of corticosterone. The ED50 was 34 mg/kg.
Animal Model: Male Balb/C mice[1]
Dosage: 5 or 10 mg/kg
Administration: IV or PO (Pharmacokinetic Analysis)
Result: Single-Dose Pharmacokinetic Parameters of BMS-823778[1]
Species Route Dose (mg/kg) Cmax (µM) Tmax (h) AUC(0-24 h) (µM•h) T1/2 (h) CLTp (mL/min/kg) Vss (L/kg) F (%)
Mouse IV* 5 - - 106 5.2 2.3 1.2 -
PO** 10 10.6 ± 1.3 3 95 - - - 44

*PO Vehicle: 0.5% Methocel/0.1% Tween 80
** IV vehicle: 10% ethanol/30% propylene glycol/60% normal saline
Clinical Trial
分子量

364.27

Formula

C18H19Cl2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-823778 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-8237781140898-87-8BMS823778BMS 82377811β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenasediet-induced obeseorally activeDIO miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
BMS-823778 hydrochloride
目录号：
HY-120643
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z