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  4. BPIQ-II hydrochloride

BPIQ-II hydrochloride  (Synonyms: PD 158294)

目录号: HY-120857
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摩尔计算器

BPIQ-II 是一种线性咪唑喹唑啉，可有效抑制表皮生长因子受体 (EGFR；IC50=8 pM) 的酪氨酸激酶活性。它对 EGFR 的选择性优于其他酪氨酸和丝氨酸/苏氨酸激酶。细胞研究表明，BPIQ-II 可以进入细胞，并通过竞争性结合 EGFR 的 ATP 位点，非常有选择性地关闭 EGF 刺激的信号传输。

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BPIQ-II hydrochloride Chemical Structure

BPIQ-II hydrochloride Chemical Structure

CAS No. : 171179-37-6

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BPIQ-II hydrochloride 相关抗体

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  • 生物活性

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生物活性

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

分子量

376.64

Formula

C15H11BrClN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BPIQ-II hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

BPIQ-II171179-37-6PD 158294PD158294PD-158294OthersInhibitorinhibitorinhibit

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