2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Buclizine

Buclizine  (Synonyms: 布克立嗪)

目录号: HY-A0128
产品使用指南

摩尔计算器

Buclizine 是具有口服活性的抗组胺、抗过敏化合物。Buclizine 是大鼠的强致畸剂，并具有抗肿瘤活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Buclizine dihydrochloride 通常具有更好的水溶性和稳定性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Buclizine Chemical Structure

Buclizine Chemical Structure

CAS No. : 82-95-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Buclizine 的其他形式现货产品:

Customer Review

Other Forms of Buclizine:

Buclizine 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Buclizine is an orally active antihistamine antiallergic compound. Buclizine is a potent teratogen in the rat and shows anti-tumor activity[1][2][3].

体外研究
(In Vitro)

Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells[2].
Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner[2].
Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Buclizine 相关抗体:

Cell Proliferation Assay[2]

Cell Line: MCF-7 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed considerable growth inhibition (IC50=19.18 μM).

Cell Cycle Analysis[2]

Cell Line: MCF-7 cells
Concentration: 9.625, 19.25, 38.5, and 77 μM
Incubation Time: 72 hours
Result: Increased the percentages of cells in the G1 phase to 73% at 77 μM.

Western Blot Analysis[2]

Cell Line: MCF-7 cells
Concentration: 0-75 μM
Incubation Time: 72 hours
Result: Decreased TCTP expression by 40% at 75 μM.
Decreased cyclin D1, cyclin D3, CDK2 and CDK4 expression after 72 h.
体内研究
(In Vivo)

Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty-seven mature female rats weighing 240±20 grams[3]
Dosage: 30, 40, 60, 100, and 200 mg/kg
Administration: 30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation
Result: Resulted in malformations in 100% of the young at a dose level of 60-100 mg/kg.
分子量

433.03

Formula

C28H33ClN2
CAS 号
中文名称

布克立嗪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Buclizine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Buclizine82-95-1布克立嗪Histamine Receptorantihistamineantiallergicanti-tumor activityteratogenMCF-7Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Buclizine
目录号：
HY-A0128
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z