Capsaicin-d₇  (Synonyms: 辣椒素-d₇; (E)-Capsaicin-d₇)

Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects^[1][2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Capsaicin 通过改变凋亡调节因子 p53、Bcl-2、Bax 和 caspase-3 的蛋白表达来抑制肺癌的发展^[3]。
Capsaicin (每只小鼠 2 μg，40 μL，注入左后爪足底表面) 可诱导小鼠出现疼痛相关行为^[5]。
Capsaicin (每只大鼠 10 μL 中 3-30 μg，足底注射) 可诱导大鼠继发性机械超敏反应 (SMH) (临床上用作潜在预测神经性疼痛的模型)^[6]。
Capsaicin (每只大鼠 25 μL 中 0-500 μg，皮下注射到右侧触须垫中心) 会引起大鼠口面部区域疼痛^[7]。
大剂量时，辣椒素可能需要在麻醉状态下给药^[8][9]。
Capsaicin 比 Dihydrocapsaicin (HY-N0361) 更刺激^[10]。
Note: 辣味呛人，请注意。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

312.46

C₁₈H₂₀D₇NO₃

404-86-4

辣椒素-d₇；辣椒碱-d₇

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90.  [Content Brief]

  [3]. Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259.  [Content Brief]

  [4]. Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7).  [Content Brief]